Department of Neurology
Mentor: Luke A. Johnson, Ph.D., Department of Neurology
Project: Effects of deep brain stimulation on parkinsonian sleep dysfunction
Dr. You aims to explore the effects of deep brain stimulation (DBS) targeting the subthalamic nucleus (STN) and globus pallidus internus (GPi) in sleep dysfunction of Parkinsonian conditions. Her study will investigate how STN-DBS and GPi-DBS change sleep quality (sleep duration, sleep architecture, sleep efficiency) and modulate neural oscillatory activity and connectivity in the cortical-subcortical networks, and characterize the relationship between sleep quality and neural effects. Her project will provide important insight into DBS mechanisms of action in the context of sleep and whether one target (STN or GPi) is more effective for improving sleep, with the ultimate goal of improving DBS for treating sleep dysfunction in PD.
