Harry T. Orr, Ph.D.

 

 

Harry Orr Bio

Institute for Translational Neuroscience

Current Publications

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Current Publications

2022

1. Coffin, S. L., Durham, M. A., Nitschke, L., Xhako, E., Brown, A. M., Revelli, J. P., Villavicencio Gonzalez, E., Lin, T., Handler, H. P., Dai, Y., Trostle, A. J., Wan, Y. W., Liu, Z., Sillitoe, R. V., Orr, H. T., & Zoghbi, H. Y. (2022). Disruption of the ATXN1-CIC complex reveals the role of additional nuclear ATXN1 interactors in spinocerebellar ataxia type 1. Neuron, S0896-6273(22)01070-4. Advance online publication. https://doi.org/10.1016/j.neuron.2022.11.016

2. Handler, H. P., Duvick, L., Mitchell, J. S., Cvetanovic, M., Reighard, M., Soles, A., Mather, K. B., Rainwater, O., Serres, S., Nichols-Meade, T., Coffin, S. L., You, Y., Ruis, B. L., O'Callaghan, B., Henzler, C., Zoghbi, H. Y., & Orr, H. T. (2022). Decreasing mutant ATXN1 nuclear localization improves a spectrum of SCA1-like phenotypes and brain region transcriptomic profiles. Neuron, S0896-6273(22)01071-6. Advance online publication. https://doi.org/10.1016/j.neuron.2022.11.017

3. Miller, W., Pruett, C. L. H., Stone, W., Eide, C., Riddle, M., Popp, C., Yousefzadeh, M., Lees, C., Seelig, D., Thompson, E., Orr, H., Niedernhofer, L., & Tolar, J. (2022). Accumulation of senescence observed in spinocerebellar ataxia type 7 mouse model. PloS one, 17(10 October), [e0275580]. https://doi.org/10.1371/journal.pone.0275580

4. Orr H. T. (2022). Cholecystokinin Activation of Cholecystokinin 1 Receptors: a Purkinje Cell Neuroprotective Pathway. Cerebellum (London, England), 10.1007/s12311-022-01428-x. Advance online publication. https://doi.org/10.1007/s12311-022-01428-x

5. Cendelin, J., Cvetanovic, M., Gandelman, M., Hirai, H., Orr, H. T., Pulst, S. M., Strupp, M., Tichanek, F., Tuma, J., & Manto, M. (2022). Consensus Paper: Strengths and Weaknesses of Animal Models of Spinocerebellar Ataxias and Their Clinical Implications. Cerebellum (London, England), 21(3), 452–481. https://doi.org/10.1007/s12311-021-01311-1

6. Lee, W. S., Al-Ramahi, I., Jeong, H. H., Jang, Y., Lin, T., Adamski, C. J., Lavery, L. A., Rath, S., Richman, R., Bondar, V. V., Alcala, E., Revelli, J. P., Orr, H. T., Liu, Z., Botas, J., & Zoghbi, H. Y. (2022). Cross-species genetic screens identify transglutaminase 5 as a regulator of polyglutamine-expanded ataxin-1. Journal of Clinical Investigation, 132(9), [e156616]. https://doi.org/10.1172/JCI156616

7. Orengo, J. P., Nitschke, L., van der Heijden, M. E., Ciaburri, N. A., Orr, H. T., & Zoghbi, H. Y. (2022). Reduction of mutant ATXN1 rescues premature death in a conditional SCA1 mouse model. JCI Insight, 7(8), [e154442]. https://doi.org/10.1172/jci.insight.154442

8. Liu, D., Nanclares, C., Simbriger, K., Fang, K., Lorsung, E., Le, N., Amorim, I. S., Chalkiadaki, K., Pathak, S. S., Li, J., Gewirtz, J. C., Jin, V. X., Kofuji, P., Araque, A., Orr, H. T., Gkogkas, C. G., & Cao, R. (2022). Autistic-like behavior and cerebellar dysfunction in Bmal1 mutant mice ameliorated by mTORC1 inhibition. Molecular psychiatry, 10.1038/s41380-022-01499-6. Advance online publication. https://doi.org/10.1038/s41380-022-01499-6

9. Nelson, D. L., Clark, J., Garber, K., Glover, T., Hassold, T., Jin, P., Orr, H. T., Sherman, S. L., Zoghbi, H., & Warren, K. L. (2022). Stephen T. Warren, Ph.D. (1953-2021): A remembrance. American Journal of Human Genetics, 109(1), 3-11. https://doi.org/10.1016/j.ajhg.2021.12.005

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Harry Orr
Director & Professor — Institute for Translational Neuroscience | Laboratory Medicine & Pathology