Dr. Mohanty’s research focuses on characterizing circuit-level neural dynamics associated with Parkinson’s disease (PD) and developing closed-loop Deep Brain Stimulation (DBS) technologies that control neural activity in real time. DBS is a highly effective therapy for managing motor signs associated with PD and is increasingly being used to treat a variety of neurological disorders. His work aims to uncover how pathological activity within basal ganglia-thalamocortical circuits gives rise to symptoms such as rigidity and bradykinesia, and to understand how these circuits respond and adapt to stimulation. To translate these insights into clinical practice, Dr. Mohanty is actively developing a next-generation neuromodulation platform that simultaneously records and processes neural signals while delivering electrical stimulation on demand. By integrating data-driven computational modeling with advanced signal processing, hardware-in-the-loop testing, and control engineering, his research establishes a framework for designing, evaluating, and translating novel closed-loop DBS strategies that dynamically adjust stimulation therapy in real time, ultimately improving outcomes for patients living with Parkinson's disease.
