Current Publications
2024
1. Gu, C., Chou, T., Widge, A. S., & Dougherty, D. D. (2024). EEG complexity in emotion conflict task in individuals with psychiatric disorders. Behavioural Brain Research, 467, Article 114997. https://doi.org/10.1016/j.bbr.2024.114997
2. Thai, M., Nair, A. U., Klimes-Dougan, B., Albott, C. S., Silamongkol, T., Corkrum, M., Hill, D., Roemer, J. W., Lewis, C. P., Croarkin, P. E., Lim, K. O., Widge, A. S., Nahas, Z., Eberly, L. E., & Cullen, K. R. (2024). Deep transcranial magnetic stimulation for adolescents with treatment-resistant depression: A preliminary dose-finding study exploring safety and clinical effectiveness. Journal of Affective Disorders, 354, 589-600. https://doi.org/10.1016/j.jad.2024.03.061
3. Webler, R. D., Morales Carrasco, C., Cooper, S. E., Chen, M., Hunt, C. O., Hennessy, S., Cao, L., Lam, C., Chiu, A., Differding, C., Todd, E., Hendrickson, T. J., Oathes, D. J., Widge, A. S., Hermosillo, R. J. M., Nelson, S. M., Fair, D. A., Lissek, S. M., & Nahas, Z. (2024). Causally Probing the Role of the Hippocampus in Fear Discrimination: A Precision Functional Mapping–Guided, Transcranial Magnetic Stimulation Study in Participants With Posttraumatic Stress Symptoms. Biological Psychiatry Global Open Science, 4(3), Article 100309. https://doi.org/10.1016/j.bpsgos.2024.100309
4. Sullivan, C. R. P., Henry, A., Lehman, J., Caola, L., Nahas, Z., Widge, A. S., Cabrera, L. Y., Randolph, A., & Wilson, S. (2024). Rewriting the Script: the Need for Effective Education to Address Racial Disparities in Transcranial Magnetic Stimulation Uptake in BIPOC Communities. Neuroethics, 17(1), Article 8. https://doi.org/10.1007/s12152-024-09542-9
5. Widge, A. S. (2024). Closing the loop in psychiatric deep brain stimulation: physiology, psychometrics, and plasticity. Neuropsychopharmacology, 49(1), 138-149. https://doi.org/10.1038/s41386-023-01643-y
6. Song, Z., Alpers, A., Warner, K., Iacobucci, F., Hoskins, E., Disterhoft, J. F., Voss, J. L., & Widge, A. S. (2024). Chronic, Reusable, Multiday Neuropixels Recordings during Free-Moving Operant Behavior. eNeuro, 11(1), Article ENEURO.0245-23.2023. https://doi.org/10.1523/ENEURO.0245-23.2023
7. Grzenda, A., & Widge, A. S. (2024). Electronic health records and stratified psychiatry: bridge to precision treatment? Neuropsychopharmacology, 49(1), 285-290. https://doi.org/10.1038/s41386-023-01724-y
2023
1. Widge, A. S., Jordan, A., Kraguljac, N. V., Sullivan, C. R. P., Wilson, S., Benton, T. D., Alpert, J. E., Carpenter, L. L., Krystal, J. H., Nemeroff, C. B., & Dzirasa, K. (2023). Structural Racism in Psychiatric Research Careers: Eradicating Barriers to a More Diverse Workforce. The American journal of psychiatry, 180(9), 645-659. https://doi.org/10.1176/appi.ajp.20220685
2. Migó, M., Chou, T., Widge, A. S., Peters, A. T., Ellard, K., Dougherty, D. D., & Deckersbach, T. (2023). Neural correlates of learning accommodation and consolidation in generalised anxiety disorder. Acta Neuropsychiatrica, 35(4), 218-225. https://doi.org/10.1017/neu.2022.16
3. Boulicault, M., Goering, S., Klein, E., Dougherty, D., & Widge, A. S. (2023). The Role of Family Members in Psychiatric Deep Brain Stimulation Trials: More Than Psychosocial Support. Neuroethics, 16(2), Article 14. https://doi.org/10.1007/s12152-023-09520-7
4. Versalovic, E., Klein, E., Goering, S., Ngo, Q., Gliske, K., Boulicault, M., Sullivan, L. S., Thomas, M. J., & Widge, A. S. (2023). Deep Brain Stimulation for Substance Use Disorders? An Exploratory Qualitative Study of Perspectives of People Currently in Treatment. Journal of addiction medicine, 17(4), E246-E254. https://doi.org/10.1097/ADM.0000000000001150
5. Nagrale, S. S., Yousefi, A., Netoff, T. I., & Widge, A. S. (2023). In silico development and validation of Bayesian methods for optimizing deep brain stimulation to enhance cognitive control. Journal of neural engineering, 20(3), Article 036015. https://doi.org/10.1088/1741-2552/acd0d5
6. Hitti, F. L., Widge, A. S., Riva-Posse, P., Malone, D. A., Okun, M. S., Shanechi, M. M., Foote, K. D., Lisanby, S. H., Ankudowich, E., Chivukula, S., Chang, E. F., Gunduz, A., Hamani, C., Feinsinger, A., Kubu, C. S., Chiong, W., Chandler, J. A., Carbunaru, R., Cheeran, B., ... Pouratian, N. (2023). Future directions in psychiatric neurosurgery: Proceedings of the 2022 American Society for Stereotactic and Functional Neurosurgery meeting on surgical neuromodulation for psychiatric disorders. Brain Stimulation, 16(3), 867-878. https://doi.org/10.1016/j.brs.2023.05.011
7. Widge, A. S. (2023). Closed-Loop Deep Brain Stimulation for Psychiatric Disorders. Harvard review of psychiatry, 31(3), 162-171. https://doi.org/10.1097/HRP.0000000000000367
8. Basu, I., Yousefi, A., Crocker, B., Zelmann, R., Paulk, A. C., Peled, N., Ellard, K. K., Weisholtz, D. S., Cosgrove, G. R., Deckersbach, T., Eden, U. T., Eskandar, E. N., Dougherty, D. D., Cash, S. S., & Widge, A. S. (2023). Closed-loop enhancement and neural decoding of cognitive control in humans. Nature Biomedical Engineering, 7(4), 576-588. https://doi.org/10.1038/s41551-021-00804-y
9. Parellada, M., Andreu-Bernabeu, Á., Burdeus, M., Cáceres, A. S. J., Urbiola, E., Carpenter, L. L., Kraguljac, N. V., McDonald, W. M., Nemeroff, C. B., Rodriguez, C. I., Widge, A. S., State, M. W., & Sanders, S. J. (2023). In Search of Biomarkers to Guide Interventions in Autism Spectrum Disorder: A Systematic Review. American Journal of Psychiatry, 180(1), 23-40. https://doi.org/10.1176/APPI.AJP.21100992
10. Wickramasuriya, D. S., Crofford, L. J., Widge, A. S., & Faghih, R. T. (2023). Hybrid Decoders for Marked Point Process Observations and External Influences. IEEE Transactions on Biomedical Engineering, PP(1), 343-353. https://doi.org/10.1109/TBME.2022.3191243
11. Webler, R. D., Oathes, D. J., van Rooij, S. J. H., Gewirtz, J. C., Nahas, Z., Lissek, S. M., & Widge, A. S. (2023). Causally mapping human threat extinction relevant circuits with depolarizing brain stimulation methods. Neuroscience and Biobehavioral Reviews, 144, Article 105005. https://doi.org/10.1016/j.neubiorev.2022.105005
12. Shin, U., Ding, C., Woods, V., Widge, A. S., & Shoaran, M. (2023). A 16-Channel Low-Power Neural Connectivity Extraction and Phase-Locked Deep Brain Stimulation SoC. IEEE Solid-State Circuits Letters, 6, 21-24. https://doi.org/10.1109/LSSC.2023.3238797
2022
1. Younk, R. L., & Widge, A. (2022). Quantifying defensive behavior and threat response through integrated headstage accelerometry. Journal of Neuroscience Methods, 382, [109725]. https://doi.org/10.1016/j.jneumeth.2022.109725
2. Harvey, P. D., Depp, C. A., Rizzo, A. A., Strauss, G. P., Spelber, D., Carpenter, L. L., Kalin, N. H., Krystal, J. H., McDonald, W. M., Nemeroff, C. B., Rodriguez, C. I., Widge, A. S., & Torous, J. (2022). Technology and Mental Health: State of the Art for Assessment and Treatment. The American journal of psychiatry, 179(12), 897-914. https://doi.org/10.1176/appi.ajp.21121254
3. Gu, L., Pathoulas, J. T., Widge, A. S., Idnani, A., & Lipner, S. R. (2022). Exacerbation of onychophagia and onychotillomania during the COVID-19 pandemic: a survey-based study. International journal of dermatology, 61(11), e412–e414. https://doi.org/10.1111/ijd.16395
4. Pinotsis, D. A., Fitzgerald, S., See, C., Sementsova, A., & Widge, A. S. (2022). Toward biophysical markers of depression vulnerability. Frontiers in Psychiatry, 13, [938694]. https://doi.org/10.3389/fpsyt.2022.938694
5. Ross, A., Paulk, A. C., Cash, S. S., Widge, A. S., & Basu, I. (2022). Neural mass model-based study of frontal-temporal theta oscillations in human subjects during the performance of a cognitive control task. Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference, 2022, 2937-2940. https://doi.org/10.1109/embc48229.2022.9871719
6. Maeng, L. Y., Rosenfeld, D., Simandl, G. J., Koehler, F., Senko, A. W., Moon, J., Varnavides, G., Murillo, M. F., Reimer, A. E., Wald, A., Anikeeva, P., & Widge, A. S. (2022). Probing Neuro-Endocrine Interactions Through Remote Magnetothermal Adrenal Stimulation. Frontiers in neuroscience, 16, 901108. https://doi.org/10.3389/fnins.2022.901108
7. Migó, M., Chou, T., Widge, A. S., Peters, A. T., Ellard, K., Dougherty, D. D., & Deckersbach, T. (2022). Neural Correlates of Learning Accommodation and Consolidation in Generalized Anxiety Disorder. Acta neuropsychiatrica, 1–29. Advance online publication. https://doi.org/10.1017/neu.2022.16
8. Wendt, K., Denison, T., Foster, G., Krinke, L., Thomson, A., Wilson, S., & Widge, A. S. (2022). Physiologically informed neuromodulation. Journal of the Neurological Sciences, 434, [120121]. https://doi.org/10.1016/j.jns.2021.120121
9. Wong, J. K., Deuschl, G., Wolke, R., Bergman, H., Muthuraman, M., Groppa, S., Sheth, S. A., Bronte-Stewart, H. M., Wilkins, K. B., Petrucci, M. N., Lambert, E., Kehnemouyi, Y., Starr, P. A., Little, S., Anso, J., Gilron, R., Poree, L., Kalamangalam, G. P., Worrell, G. A., ... Okun, M. S. (2022). Proceedings of the Ninth Annual Deep Brain Stimulation Think Tank: Advances in Cutting Edge Technologies, Artificial Intelligence, Neuromodulation, Neuroethics, Pain, Interventional Psychiatry, Epilepsy, and Traumatic Brain Injury. Frontiers in Human Neuroscience, 16, [813387]. https://doi.org/10.3389/fnhum.2022.813387
10. Paulk, A. C., Zelmann, R., Crocker, B., Widge, A. S., Dougherty, D. D., Eskandar, E. N., Weisholtz, D. S., Richardson, R. M., Cosgrove, G. R., Williams, Z. M., & Cash, S. S. (2022). Local and distant cortical responses to single pulse intracranial stimulation in the human brain are differentially modulated by specific stimulation parameters. Brain Stimulation, 15(2), 491-508. https://doi.org/10.1016/j.brs.2022.02.017
11. Widge, A. S., Zhang, F., Gosai, A., Papadimitrou, G., Wilson-Braun, P., Tsintou, M., Palanivelu, S., Noecker, A. M., McIntyre, C. C., O'Donnell, L., McLaughlin, N., Greenberg, B. D., Makris, N., Dougherty, D. D., & Rathi, Y. (2022). Patient-specific connectomic models correlate with, but do not reliably predict, outcomes in deep brain stimulation for obsessive-compulsive disorder. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 47(4), 965–972. https://doi.org/10.1038/s41386-021-01199-9
12. Redish, A. D., Kepecs, A., Anderson, L. M., Calvin, O. L., Grissom, N. M., Haynos, A. F., Heilbronner, S. R., Herman, A. B., Jacob, S., Ma, S., Vilares, I., Vinogradov, S., Walters, C. J., Widge, A. S., Zick, J., & Zilverstand, A. (2022). Computational validity: using computation to translate behaviours across species. Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 377(1844), 20200525. https://doi.org/10.1098/rstb.2020.0525
13. Hill, K. P., Gold, M. S., Nemeroff, C. B., McDonald, W., Grzenda, A., Widge, A. S., Rodriguez, C., Kraguljac, N. V., Krystal, J. H., & Carpenter, L. L. (2022). Risks and Benefits of Cannabis and Cannabinoids in Psychiatry. The American journal of psychiatry, 179(2), 98-109. https://doi.org/10.1176/appi.ajp.2021.21030320
14. Schatza, M. J., Blackwood, E. B., Nagrale, S. S., & Widge, A. S. (2022). Toolkit for Oscillatory Real-time Tracking and Estimation (TORTE). Journal of Neuroscience Methods, 366, [109409]. https://doi.org/10.1016/j.jneumeth.2021.109409 Haynos, A. F., Widge, A. S., Anderson, L. M., & Redish, A. D. (2022). Beyond Description and Deficits: How Computational Psychiatry Can Enhance an Understanding of Decision-Making in Anorexia Nervosa. Current psychiatry reports, 24(1), 77-87. https://doi.org/10.1007/s11920-022-01320-9
15. Dastin-Van Rijn, E. M., König, S. D., Carlson, D., Goel, V., Grande, A., Nixdorf, D. R., Benish, S., Widge, A. S., Nahas, Z., Park, M., Netoff, T. I., Herman, A. B., & Darrow, D. P. (2022). Personalizing dual-target cortical stimulation with bayesian parameter optimization successfully treats central post-stroke pain: A case report. Brain Sciences, 12(1), [25]. https://doi.org/10.3390/brainsci12010025
2021
1. Avvaru, S. V. S., Provenza, N. R., Widge, A. S., & Parhi, K. K. (2021). Spectral Features Based Decoding of Task Engagement: The Role of Theta and High Gamma Bands in Cognitive Control. Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference, 2021, 6062-6065. https://doi.org/10.1109/EMBC46164.2021.9630923
2. Avvaru, S. V. S., Provenza, N. R., Widge, A. S., & Parhi, K. K. (2021). Decoding Human Cognitive Control Using Functional Connectivity of Local Field Potentials. Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference, 2021, 451-454. https://doi.org/10.1109/EMBC46164.2021.9630706
3. Kumar, A., Nemeroff, C. B., Cooper, J. J., Widge, A., Rodriguez, C., Carpenter, L., & McDonald, W. M. (2021). Amyloid and Tau in Alzheimer's Disease: Biomarkers or Molecular Targets for Therapy? Are We Shooting the Messenger? American Journal of Psychiatry, 178(11), 1014-1025. https://doi.org/10.1176/appi.ajp.2021.19080873
4. Widge, A. S., Zhang, F., Gosai, A., Papadimitrou, G., Wilson-Braun, P., Tsintou, M., Palanivelu, S., Noecker, A. M., McIntyre, C. C., O’Donnell, L., McLaughlin, N. C. R., Greenberg, B. D., Makris, N., Dougherty, D. D., & Rathi, Y. (2021). Patient-specific connectomic models correlate with, but do not reliably predict, outcomes in deep brain stimulation for obsessive-compulsive disorder. Neuropsychopharmacology, 47(4), 965-972. https://doi.org/10.1038/s41386-021-01199-9
5. Wodeyar, A., Schatza, M., Widge, A. S., Eden, U. T., & Kramer, M. A. (2021). A state space modeling approach to real-time phase estimation. eLife, 10, Article e68803. https://doi.org/10.7554/eLife.68803
6. Crocker, B., Ostrowski, L., Williams, Z. M., Dougherty, D. D., Eskandar, E. N., Widge, A. S., Chu, C. J., Cash, S. S., & Paulk, A. C. (2021). Local and distant responses to single pulse electrical stimulation reflect different forms of connectivity. NeuroImage, 237, Article 118094. https://doi.org/10.1016/j.neuroimage.2021.118094
7. Davis, R. A., Giordano, J., Hufford, D. B., Sheth, S. A., Warnke, P., Widge, A. S., Richardson, R. M., Rosenow, J. M., Rossi, P. J., Storch, E. A., Winston, H., Zboyan, J. A., Dougherty, D. D., Foote, K. D., Goodman, W. K., McLaughlin, N. C. R., Ojemann, S., Rasmussen, S., Abosch, A., & Okun, M. S. (2021). Restriction of Access to Deep Brain Stimulation for Refractory OCD: Failure to Apply the Federal Parity Act. Frontiers in Psychiatry, 12, Article 706181. https://doi.org/10.3389/fpsyt.2021.706181
8. Grzenda, A., Kraguljac, N. V., McDonald, W. M., Nemeroff, C., Torous, J., Alpert, J. E., Rodriguez, C. I., & Widge, A. S. (2021). Evaluating the Machine Learning Literature: A Primer and User’s Guide for Psychiatrists. American Journal of Psychiatry, 178(8), 715-729. https://doi.org/10.1176/appi.ajp.2020.20030250
9. Kraguljac, N. V., McDonald, W. M., Widge, A. S., Rodriguez, C. I., Tohen, M., & Nemeroff, C. B. (2021). Neuroimaging Biomarkers in Schizophrenia. American Journal of Psychiatry, 178(6), 509-521. https://doi.org/10.1176/appi.ajp.2020.20030340
10. de Oliveira, A. R., Reimer, A. E., Simandl, G. J., Nagrale, S. S., & Widge, A. S. (2021). Lost in translation: no effect of repeated optogenetic cortico-striatal stimulation on compulsivity in rats. Translational psychiatry, 11(1), Article 315. https://doi.org/10.1038/s41398-021-01448-x
11. McLaughlin, N. C. R., Dougherty, D. D., Eskandar, E., Ward, H., Foote, K. D., Malone, D. A., Machado, A., Wong, W., Sedrak, M., Goodman, W., Kopell, B. H., Issa, F., Shields, D. C., Abulseoud, O. A., Lee, K., Frye, M. A., Widge, A. S., Deckersbach, T., Okun, M. S., ... Greenberg, B. D. (2021). Double blind randomized controlled trial of deep brain stimulation for obsessive-compulsive disorder: Clinical trial design. Contemporary Clinical Trials Communications, 22, Article 100785. https://doi.org/10.1016/j.conctc.2021.100785
12. Dubreuil-Vall, L., Gomez-Bernal, F., Villegas, A. C., Cirillo, P., Surman, C., Ruffini, G., Widge, A. S., & Camprodon, J. A. (2021). Transcranial Direct Current Stimulation to the Left Dorsolateral Prefrontal Cortex Improves Cognitive Control in Patients With Attention-Deficit/Hyperactivity Disorder: A Randomized Behavioral and Neurophysiological Study. Biological Psychiatry: Cognitive Neuroscience and Neuroimaging, 6(4), 439-448. https://doi.org/10.1016/j.bpsc.2020.11.006
13. Pathoulas, J. T., Olson, S. J., Idnani, A., Farah, R. S., Hordinsky, M. K., & Widge, A. S. (2021). Cross-sectional survey examining skin picking and hair pulling disorders during the COVID-19 pandemic. Journal of the American Academy of Dermatology, 84(3), 771-773. https://doi.org/10.1016/j.jaad.2020.11.011
14. Sullivan, C. R. P., Olsen, S., & Widge, A. S. (2021). Deep brain stimulation for psychiatric disorders: From focal brain targets to cognitive networks. NeuroImage, 225, Article 117515. https://doi.org/10.1016/j.neuroimage.2020.117515
15. Avvaru, S., Peled, N., Provenza, N. R., Widge, A. S., & Parh, K. K. (2021). Region-Level Functional and Effective Network Analysis of Human Brain During Cognitive Task Engagement. IEEE Transactions on Neural Systems and Rehabilitation Engineering, 29, 1651-1660. https://doi.org/10.1109/TNSRE.2021.3105432
2020
1. Lo, M. C., Younk, R., & Widge, A. S. (2020). Paired Electrical Pulse Trains for Controlling Connectivity in Emotion-Related Brain Circuitry. IEEE Transactions on Neural Systems and Rehabilitation Engineering, 28(12), 2721-2730. Article 9222028. https://doi.org/10.1109/TNSRE.2020.3030714
2. Zelmann, R., Paulk, A. C., Basu, I., Sarma, A., Yousefi, A., Crocker, B., Eskandar, E., Williams, Z., Cosgrove, G. R., Weisholtz, D. S., Dougherty, D. D., Truccolo, W., Widge, A. S., & Cash, S. S. (2020). CLoSES: A platform for closed-loop intracranial stimulation in humans. NeuroImage, 223, Article 117314. https://doi.org/10.1016/j.neuroimage.2020.117314
3. Sanchez, C., Grzenda, A., Varias, A., Widge, A. S., Carpenter, L. L., McDonald, W. M., Nemeroff, C. B., Kalin, N. H., Martin, G., Tohen, M., Filippou-Frye, M., Ramsey, D., Linos, E., Mangurian, C., & Rodriguez, C. I. (2020). Social media recruitment for mental health research: A systematic review. Comprehensive Psychiatry, 103, Article 152197. https://doi.org/10.1016/j.comppsych.2020.152197
4. Olsen, S. T., Basu, I., Bilge, M. T., Kanabar, A., Boggess, M. J., Rockhill, A. P., Gosai, A. K., Hahn, E., Peled, N., Ennis, M., Shiff, I., Fairbank-Haynes, K., Salvi, J. D., Cusin, C., Deckersbach, T., Williams, Z., Baker, J. T., Dougherty, D. D., & Widge, A. S. (2020). Case Report of Dual-Site Neurostimulation and Chronic Recording of Cortico-Striatal Circuitry in a Patient With Treatment Refractory Obsessive Compulsive Disorder. Frontiers in Human Neuroscience, 14, Article 569973. https://doi.org/10.3389/fnhum.2020.569973
5. Dwyer, J. B., Aftab, A., Widge, A., Rodriguez, C. I., Carpenter, L. L., Nemeroff, C. B., McDonald, W. M., & Kalin, N. H. (2020). Hormonal treatments for major depressive disorder: State of the art. American Journal of Psychiatry, 177(8), 686-705. https://doi.org/10.1176/appi.ajp.2020.19080848
6. Work Group on Biomarkers and Novel Treatments, & Division of the American Psychiatric Association Council of Research (2020). Psychedelics and psychedelic-assisted psychotherapy. American Journal of Psychiatry, 177(5), 391-410. https://doi.org/10.1176/appi.ajp.2019.19010035
7. Wang, J., & Widge, A. S. (2020). Neuromodulation approaches to mood disorders. Psychiatric Times, 37(2), 22-24.
8. AMA-RFS Task Force on Resident/Fellow Physician Satisfaction (2020). Support, technology and mental health: correlates of trainee workplace satisfaction. Perspectives on Medical Education, 9(1), 31-40. https://doi.org/10.1007/s40037-019-00555-2
9. Rosenfeld, D., Senko, A. W., Moon, J., Yick, I., Varnavides, G., Gregureć, D., Koehler, F., Chiang, P. H., Christiansen, M. G., Maeng, L. Y., Widge, A. S., & Anikeeva, P. (2020). Transgene-free remote magnetothermal regulation of adrenal hormones. Science Advances, 6(15), Article eaaz3734. https://doi.org/10.1126/sciadv.aaz3734
