University of Minnesota awarded $21M to lead research revealing effects of vagus nerve stimulation in humans

Vagus Nerve

University of Minnesota Twin Cities researchers are leading a comprehensive global clinical study that seeks to reveal the functional effects of vagus nerve stimulation (VNS) across the human body 

This is a multidisciplinary, multi-institutional research study that will be led by the University of Minnesota. A hearty congratulations goes to Ziad Nahas who is the study’s co-Principal Investigator and played a key role in securing the grant.

The Research Evaluating Vagal Excitation and Anatomical Links (REVEAL) project is a $21 million National Institutes of Health-funded project that will take place over three years. REVEAL aims to study the anatomical connections and functional effects of vagus nerve stimulation, or VNS, which is an ​​FDA-approved treatment for epilepsy and depression. 


The $21 million 3-year NIH project is called, “Research Evaluating Vagal Excitation and Anatomical Links (REVEAL).” Its goal is to study the anatomical connections

and functional effects of vagus nerve stimulation, or VNS,  which is an ​​FDA-approved treatment for epilepsy and depression.

In the press release about the new grant, Ziad said, “VNS has a proven record treating refractory epilepsy and depression. The exciting aspect of REVEAL is that it will set the stage for novel therapeutic applications of VNS to autonomic, immune, cardiovascular, and metabolic diseases.”

Institutions collaborating in the study include Mayo Clinic in Minnesota; Monash University in Australia; Stanford School of Medicine; Washington University in St. Louis; Medical University of South Carolina; Sheppard Pratt in Maryland; and Scuola Superiore Sant’Anna in Italy. Company partners include LivaNova, BRIGHT Research Partners, and BIOS Health.

This study showcases our reputation in leading vagus nerve stimulation research and the impact that it has on patient treatment. We are proud of Ziad’s leadership role and look forward to the results the research team will share with the world.

Read more here: https://med.umn.edu/news-events/university-minnesota-awarded-21m-lead-research-revealing-effects-vagus-nerve-stimulation-humans