Leonardo Brito de Almeida, M.D., M.S.

Leonardo Brito de Almeida Bio

 

Current Publications

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Current Publications

2024

1. Oxenford, S., Ríos, A. S., Hollunder, B., Neudorfer, C., Boutet, A., Elias, G. J. B., Germann, J., Loh, A., Deeb, W., Salvato, B., Almeida, L., Foote, K. D., Amaral, R., Rosenberg, P. B., Tang-Wai, D. F., Wolk, D. A., Burke, A. D., Sabbagh, M. N., Salloway, S., ... Horn, A. (2024). WarpDrive: Improving spatial normalization using manual refinements. Medical Image Analysis, 91, Article 103041. https://doi.org/10.1016/j.media.2023.103041

2023

1. Eisinger, R. S., Okun, M. S., Cernera, S., Cagle, J., Beke, M., Ramirez-Zamora, A., Kim, B. H., Barbosa, D. A. N., Qiu, L., Vaswani, P., Aamodt, W. W., Halpern, C. H., Foote, K. D., Gunduz, A., & Almeida, L. (2023). Weight and survival after deep brain stimulation for Parkinson's disease. Parkinsonism and Related Disorders, 115, Article 105810. https://doi.org/10.1016/j.parkreldis.2023.105810

2. Cagle, J. N., Johnson, K. A., Almeida, L., Wong, J. K., Ramirez-Zamora, A., Okun, M. S., Foote, K. D., & de Hemptinne, C. (2023). Brain Recording Analysis and Visualization Online (BRAVO): An open-source visualization tool for deep brain stimulation data. Brain Stimulation, 16(3), 793-797. https://doi.org/10.1016/j.brs.2023.04.018

3. Wong, J. K., Lopes, J. M. L. J., Hu, W., Wang, A., Au, K. L. K., Stiep, T., Frey, J., Toledo, J. B., Raike, R. S., Okun, M. S., & Almeida, L. (2023). Double blind, nonrandomized crossover study of active recharge biphasic deep brain stimulation for primary dystonia. Parkinsonism and Related Disorders, 109, Article 105328. https://doi.org/10.1016/j.parkreldis.2023.105328

4. Holland, M. T., Alvarado-Gonzalez, A., Wong, J. K., Almeida, L. B. D., Wagle Shukla, A., Deeb, W., Patterson, A., Okun, M. S., & Foote, K. D. (2023). Hematoma-induced Twiddler-like phenomenon as a presentation of DBS hardware failure: Case report. Frontiers in Human Neuroscience, 17, Article 1160237. https://doi.org/10.3389/fnhum.2023.1160237

5. Marsili, L., Keeling, E. G., Maciel, R., Contarino, M. F., Zutt, R., Okun, M. S., Almeida, L., Deeb, W., Kern, D., Macias-Garcia, D., Carrillo, F., Mir, P., Merola, A., Espay, A. J., & Fasano, A. (2023). Functional Movement Disorders and Deep Brain Stimulation: A Multi-Center Study. Movement Disorders Clinical Practice, 10(1), 94-100. https://doi.org/10.1002/mdc3.13609

2022

1. Ríos, A. S., Oxenford, S., Neudorfer, C., Butenko, K., Li, N., Rajamani, N., Boutet, A., Elias, G. J. B., Germann, J., Loh, A., Deeb, W., Wang, F., Setsompop, K., Salvato, B., Almeida, L. B. D., Foote, K. D., Amaral, R., Rosenberg, P. B., Tang-Wai, D. F., ... Horn, A. (2022). Optimal deep brain stimulation sites and networks for stimulation of the fornix in Alzheimer’s disease. Nature communications, 13(1), Article 7707. https://doi.org/10.1038/s41467-022-34510-3

2. Fearon, C., Rawal, S., Olszewska, D., Alcaide-Leon, P., Kern, D. S., Sharma, S., Jaiswal, S. K., Murthy, J. M. K., Ha, A. D., Schwartz, R. S., Fung, V. S. C., Spears, C., Tholanikunnel, T., Almeida, L., Hatano, T., Oji, Y., Hattori, N., Shubham, S., Kumar, H., ... Lang, A. E. (2022). Neuroimaging Pearls from the MDS Congress Video Challenge. Part 2: Acquired Disorders. Movement Disorders Clinical Practice, 9(3), 311-325. https://doi.org/10.1002/mdc3.13415

3. Au, K. L. K., Lopes, J. L. M. L. J., Kraus, A., Patton, K., Warren, L., Gao, H., Wong, J. K., Moore, K., Toledo, J. B., Stiep, T., Frey, J., Tholanikunnel, T., Hess, C., Almeida, L., Ramirez-Zamora, A., & Okun, M. S. (2022). A randomized clinical trial of burst vs. spaced physical therapy for Parkinsons disease. Parkinsonism and Related Disorders, 97, 57-62. https://doi.org/10.1016/j.parkreldis.2022.02.021

4. Wong, J. K., Patel, B., Middlebrooks, E. H., Hilliard, J. D., Foote, K. D., Okun, M. S., & Almeida, L. (2022). Connectomic analysis of unilateral dual-lead thalamic deep brain stimulation for treatment of multiple sclerosis tremor. Brain Communications, 4(2), Article fcac063. https://doi.org/10.1093/braincomms/fcac063

2021

1. Neudorfer, C., Elias, G. J. B., Jakobs, M., Boutet, A., Germann, J., Narang, K., Loh, A., Paff, M., Horn, A., Kucharczyk, W., Deeb, W., Salvato, B., Almeida, L., Foote, K. D., Rosenberg, P. B., Tang-Wai, D. F., Anderson, W. S., Mari, Z., Ponce, F. A., ... Lozano, A. M. (2021). Mapping autonomic, mood and cognitive effects of hypothalamic region deep brain stimulation. Brain, 144(9), 2837-2851. https://doi.org/10.1093/brain/awab170

2. Holanda, V. M., Eisinger, R. S., Almeida, L., Tsuboi, T., Wang, H., Okun, M. S., Deeb, W., Patterson, A., Wagle Shukla, A., Lobo Lopes, J., & Foote, K. D. (2021). Evolution of Globus Pallidus Targeting for Parkinson's and Dystonia Deep Brain Stimulation: A 15-Year Experience. Frontiers in Neurology, 12, Article 679918. https://doi.org/10.3389/fneur.2021.679918

3. Tsuboi, T., Lopes, J. L. M. L. J., Moore, K., Patel, B., Legacy, J., Ratajska, A. M., Bowers, D., Eisinger, R. S., Almeida, L., Foote, K. D., Okun, M. S., & Ramirez-Zamora, A. (2021). Long-term clinical outcomes of bilateral GPi deep brain stimulation in advanced Parkinson's disease: 5 years and beyond. Journal of neurosurgery, 135(2), 601-610. https://doi.org/10.3171/2020.6.JNS20617

4. Tsuboi, T., Wong, J. K., Eisinger, R. S., Okromelidze, L., Burns, M. R., Ramirez-Zamora, A., Almeida, L., Wagle Shukla, A., Foote, K. D., Okun, M. S., Grewal, S. S., & Middlebrooks, E. H. (2021). Comparative connectivity correlates of dystonic and essential tremor deep brain stimulation. Brain, 144(6), 1774-1786. https://doi.org/10.1093/brain/awab074

5. Germann, J., Elias, G. J. B., Boutet, A., Narang, K., Neudorfer, C., Horn, A., Loh, A., Deeb, W., Salvato, B., Almeida, L., Foote, K. D., Rosenberg, P. B., Tang-Wai, D. F., Wolk, D. A., Burke, A. D., Salloway, S., Sabbagh, M. N., Chakravarty, M. M., Smith, G. S., ... Lozano, A. M. (2021). Brain structures and networks responsible for stimulation-induced memory flashbacks during forniceal deep brain stimulation for Alzheimer's disease. Alzheimer's and Dementia, 17(5), 777-787. https://doi.org/10.1002/alz.12238

6. Wong, J. K., Hu, W., Barmore, R., Lopes, J., Moore, K., Legacy, J., Tahafchi, P., Jackson, Z., Judy, J. W., Raike, R. S., Wang, A., Tsuboi, T., Okun, M. S., & Almeida, L. (2021). Safety and Tolerability of Burst-Cycling Deep Brain Stimulation for Freezing of Gait in Parkinson’s Disease. Frontiers in Human Neuroscience, 15, Article 651168. https://doi.org/10.3389/fnhum.2021.651168

7. Tsuboi, T., Charbel, M., Peterside, D. T., Rana, M., Elkouzi, A., Deeb, W., Ramirez-Zamora, A., Lemos Melo Lobo Jofili Lopes, J., Almeida, L., Zeilman, P. R., Eisinger, R. S., Foote, K. D., Okromelidze, L., Grewal, S. S., Okun, M. S., & Middlebrooks, E. H. (2021). Pallidal Connectivity Profiling of Stimulation-Induced Dyskinesia in Parkinson's Disease. Movement Disorders, 36(2), 380-388. https://doi.org/10.1002/mds.28324

8. Giacobbe, A., Au, K. L. K., Nguyen, O. T., Moore, K., Dinh, E., Ramirez-Zamora, A., Okun, M. S., & Almeida, L. (2021). Geospatial analysis of persons with movement disorders living in underserved regions. Tremor and Other Hyperkinetic Movements, 11, 1-8. https://doi.org/10.5334/tohm.635

9. Kim, J. Y., Hicks, J., de Almeida, L. B., Wagle-Shukla, A., Zeilman, P., & Hegland, K. (2021). Impact of deep brain stimulation surgery on speech and swallowing in patients with essential tremor. Clinical Archives of Communication Disorders, 6(2), 71-78. https://doi.org/10.21849/CACD.2021.00318

10. Patel, B., Chiu, S., Wong, J. K., Patterson, A., Deeb, W., Burns, M., Zeilman, P., Wagle-Shukla, A., Almeida, L., Okun, M. S., & Ramirez-Zamora, A. (2021). Deep brain stimulation programming strategies: segmented leads, independent current sources, and future technology. Expert Review of Medical Devices, 18(9), 875-891. https://doi.org/10.1080/17434440.2021.1962286

2020

1. Opri, E., Cernera, S., Molina, R., Eisinger, R. S., Cagle, J. N., Almeida, L., Denison, T., Okun, M. S., Foote, K. D., & Gunduz, A. (2020). Chronic embedded cortico-thalamic closed-loop deep brain stimulation for the treatment of essential tremor. Science Translational Medicine, 12(572), Article eaay7680. https://doi.org/10.1126/SCITRANSLMED.AAY7680

2. Zhang, C., Wang, L., Hu, W., Wang, T., Zhao, Y., Pan, Y., Almeida, L., Ramirez-Zamora, A., Sun, B., & Li, D. (2020). Combined unilateral subthalamic nucleus and contralateral globus pallidus interna deep brain stimulation for treatment of Parkinson disease: A pilot study of symptom-tailored stimulation. Neurosurgery, 87(6), 1139-1147. https://doi.org/10.1093/neuros/nyaa201

3. Cernera, S., Eisinger, R. S., Wong, J. K., Ho, K. W. D., Lopes, J. L., To, K., Carbunaru, S., Ramirez-Zamora, A., Almeida, L., Foote, K. D., Okun, M. S., & Gunduz, A. (2020). Long-term Parkinson’s disease quality of life after staged DBS: STN vs GPi and first vs second lead. npj Parkinson's Disease, 6(1), Article 13. https://doi.org/10.1038/s41531-020-0115-3

4. Wong, J. K., Armstrong, M. J., Almeida, L., Wagle Shukla, A., Patterson, A., Okun, M. S., & Malaty, I. A. (2020). Case Report: Globus Pallidus Internus (GPi) Deep Brain Stimulation Induced Keyboard Typing Dysfunction. Frontiers in Human Neuroscience, 14, Article 583441. https://doi.org/10.3389/fnhum.2020.583441

5. Middlebrooks, E. H., Domingo, R. A., Vivas-Buitrago, T., Okromelidze, L., Tsuboi, T., Wong, J. K., Eisinger, R. S., Almeida, L., Burns, M. R., Horn, A., Uitti, R. J., Wharen, R. E., Holanda, V. M., & Grewal, S. S. (2020). Neuroimaging advances in deep brain stimulation: Review of indications, anatomy, and brain connectomics. American Journal of Neuroradiology, 41(9), 1558-1568. https://doi.org/10.3174/ajnr.A6693

6. Johnson, K. A., Duffley, G., Anderson, D. N., Ostrem, J. L., Welter, M. L., Baldermann, J. C., Kuhn, J., Huys, D., Visser-Vandewalle, V., Foltynie, T., Zrinzo, L., Hariz, M., Leentjens, A. F. G., Mogilner, A. Y., Pourfar, M. H., Almeida, L., Gunduz, A., Foote, K. D., Okun, M. S., & Butson, C. R. (2020). Structural connectivity predicts clinical outcomes of deep brain stimulation for Tourette syndrome. Brain, 143(8), 2607-2623. https://doi.org/10.1093/brain/awaa188

7. Zhang, C., Ramirez-Zamora, A., Meng, F., Lin, Z., Lai, Y., Li, D., Chang, J., Morishita, T., Inoue, T., Fujioka, S., Oyama, G., Coyne, T., Voon, V., Doshi, P. K., Wu, Y., Liu, J., Patel, B., Almeida, L., Wagle Shukla, A. A., ... Okun, M. S. (2020). An International Survey of Deep Brain Stimulation Utilization in Asia and Oceania: The DBS Think Tank East. Frontiers in Human Neuroscience, 14, Article 162. https://doi.org/10.3389/fnhum.2020.00162

8. Eisinger, R. S., Martinez-Ramirez, D., Ramirez-Zamora, A., Hess, C. W., Almeida, L., Okun, M. S., & Gunduz, A. (2020). Parkinson's disease motor subtype changes during 20 years of follow-up. Parkinsonism and Related Disorders, 76, 104-107. https://doi.org/10.1016/j.parkreldis.2019.05.024

9. Tsuboi, T., Au, K. L. K., Deeb, W., Almeida, L., Foote, K. D., Okun, M. S., & Ramirez-Zamora, A. (2020). Motor outcomes and adverse effects of deep brain stimulation for dystonic tremor: A systematic review. Parkinsonism and Related Disorders, 76, 32-41. https://doi.org/10.1016/j.parkreldis.2020.06.008

10. Tsuboi, T., Lemos Melo Lobo Jofili Lopes, J., Patel, B., Legacy, J., Moore, K., Eisinger, R. S., Almeida, L., Foote, K. D., Okun, M. S., & Ramirez-Zamora, A. (2020). Parkinson's disease motor subtypes and bilateral GPi deep brain stimulation: One-year outcomes. Parkinsonism and Related Disorders, 75, 7-13. https://doi.org/10.1016/j.parkreldis.2020.05.004

11. Wong, J. K., Middlebrooks, E. H., Grewal, S. S., Almeida, L., Hess, C. W., & Okun, M. S. (2020). A Comprehensive Review of Brain Connectomics and Imaging to Improve Deep Brain Stimulation Outcomes. Movement Disorders, 35(5), 741-751. https://doi.org/10.1002/mds.28045

12. Tsuboi, T., Wong, J. K., Almeida, L., Hess, C. W., Wagle Shukla, A., Foote, K. D., Okun, M. S., & Ramirez-Zamora, A. (2020). A pooled meta-analysis of GPi and STN deep brain stimulation outcomes for cervical dystonia. Journal of Neurology, 267(5), 1278-1290. https://doi.org/10.1007/s00415-020-09703-9

13. Wong, J. K., Hess, C. W., Almeida, L., Middlebrooks, E. H., Christou, E. A., Patrick, E. E., Shukla, A. W., Foote, K. D., & Okun, M. S. (2020). Deep brain stimulation in essential tremor: targets, technology, and a comprehensive review of clinical outcomes. Expert Review of Neurotherapeutics, 20(4), 319-331. https://doi.org/10.1080/14737175.2020.1737017

14. Ramirez-Zamora, A., Giordano, J., Gunduz, A., Alcantara, J., Cagle, J. N., Cernera, S., Difuntorum, P., Eisinger, R. S., Gomez, J., Long, S., Parks, B., Wong, J. K., Chiu, S., Patel, B., Grill, W. M., Walker, H. C., Little, S. J., Gilron, R., Tinkhauser, G., ... Michael S, O. (2020). Proceedings of the Seventh Annual Deep Brain Stimulation Think Tank: Advances in Neurophysiology, Adaptive DBS, Virtual Reality, Neuroethics and Technology. Frontiers in Human Neuroscience, 14, Article 54. https://doi.org/10.3389/fnhum.2020.00054

15. Okromelidze, L., Tsuboi, T., Eisinger, R. S., Burns, M. R., Charbel, M., Rana, M., Grewal, S. S., Lu, C. Q., Almeida, L., Foote, K. D., Okun, M. S., & Middlebrooks, E. H. (2020). Functional and structural connectivity patterns associated with clinical outcomes in deep brain stimulation of the globus pallidus internus for generalized dystonia. American Journal of Neuroradiology, 41(3), 508-514. https://doi.org/10.3174/ajnr.A6429

16. Chiu, S. Y., Deeb, W., Zeilman, P., Ramirez-Zamora, A., Patterson, A., Patel, B., Foote, K. D., Okun, M. S., Patel, A., & Almeida, L. (2020). Brain atrophy following deep brain stimulation: Management of a moving target. Tremor and Other Hyperkinetic Movements, 10, 1-7. Article 46. https://doi.org/10.5334/tohm.546

17. Chiu, S. Y., Tsuboi, T., Hegland, K. W., Herndon, N. E., Shukla, A. W., Patterson, A., Almeida, L., Foote, K. D., Okun, M. S., & Ramirez-Zamora, A. (2020). Dysarthria and Speech Intelligibility following Parkinson's Disease Globus Pallidus Internus Deep Brain Stimulation. Journal of Parkinson's Disease, 10(4), 1493-1502. https://doi.org/10.3233/JPD-202246

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Leo Brito de Almeida
Neuromodulation Scholar, Associate Professor — Neurology